Leaders in pyrogen testing.

With the highest reactivity, sensitivity, reproducibility and batch sizes of 2,000 – MAT BioTech's Monocyte Activation Test (MAT) kit provides the best performing pyrogen test available on the market. Save legal fees and save lives.

 

Changes in EP regulations for pyrogen tests are now being enforced. 

1. No more use of Rabbits

RPT no longer permitted as there is now a viable in vitro alternative

2. Obliged risk assessments

If using BET as batch release test, NEP tests are now also mandatory

3. MM6 no full pyrogen test

MM6 Cell-line alone not suitable for detecting NEPs

Recognising the seriousness of instances where NEP contaminations occur, the EP now mandates consistent testing of NEPs in-process, or at batch release of all parenteral drugs. EP specifically recommends the MAT. 

Endotoxin and 

non-Endotoxin tests are required.

For every producer of parenteral drugs or medical devices distributed in Europe.

Using MAT is also relevant for Biotech companies, Pharmacies performing in-house pyrogen testing, Test service and diagnostic laboratories and Clinical Research Organizations (CRO)

One MAT kit to rule them all (that's ours).

10,000

Highest reactivity

0.5 EU/ml LPS can produce 10 thousand Picogram/ml IL6

0.004

Highest sensitivity

A Lower Limit of Detection of

0.004 endotoxin/ml

2,000

Highest reproducibility

Consistent results within and across our batches of up to 2000 vials

Explore the background and context of pyrogen testing.

BACKGROUND

What the journey of keeping drugs safe from pyrogens has looked like: from Rabbit Pyrogen Tests, to Bacterial Endotoxin Tests and now MAT.

EDUCATION

How do you define pyrogens?

What constitutes an exogenous versus an endogenous pyrogen and the difference between those that are endotoxin and non-endotoxin.

MARKET

What are the different types of kit available?

What differentiates the commercialised MAT kits that are currently available on the market and how to pick the most suitable one.

You'll be in 

good company.

Join some of the largest pharmaceutical, bioscience and medical device companies in the world who partner with us for Monocyte Activation Testing. 

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Exclusive European distributers of CTL-MAT