Transitioning from the Rabbit Pyrogen Test (RPT)
Menu
In-vitro pyrogen testing for life changing products
With an LoD of 0.004 EU/ml and batch sizes of up to 2,000 kits, our CTL-MAT Monocyte Activation Test helps big pharmaceuticals release life changing products, safely.
Test it all with MAT BioTech
Whether you produce parenteral drugs or medical devices, we'll provide you with the MAT kit and services you need to robustly test for all endotoxin and non-endotoxin pyrogenic contaminations. Release your products, safer than ever before.
Employ MAT as your in-vitro batch release pyrogen test
Often for intrinsically pyrogenic products or medical devices at risk of catching material-mediated pyrogens. Detect and quantify both endotoxins and Non-endotoxin pyrogens with one assay at every release.
Assess risk of non-endotoxin pyrogens (NEPs) using MAT
If you're using LAL or rFC as your release assay, the Ph. Eur. recommends the in-vitro MAT as the mandatory NEP risk assessment.
Outsource your testing to experienced MAT experts
Our network of GMP certified service partners have the MAT experience and know-how to save you time and resources.
We'll deliver results that others simply can't.
0.004
EU/ml LoD
The lowest limit of detection
Increases your product's MVD, letting you overcome almost any stimulatory or inhibitory effects caused by interfering factors.
2,000
Kits per batch
The largest MAT kit batches
You'll always have consistent conditions across different trials, validation stages and batch releases.
15
Years experience
The longest MAT history
Call upon a team comprising the very first pioneers of MAT. Whatever your challenge, we've already seen and overcome it.
We'll help you —
Replace RPT with Ph. Eur.'s in-vitro replacement
The European Pharmacopeia has committed to seeing all Rabbit Pyrogen testing completely phased out by 2026. MAT BioTech is now partnering with the biggest Pharma to do so.
Test medical devices by direct incubation where BET/RPT fail
Rather than testing rinsing solutions like BET and RPT which miss insoluble pyrogens, MAT is the only assay that successfully tests and detects the entire surface contamination of devices by direct incubation.
Overcome low endotoxin recovery (LER) effects
Firstly, thanks to our kit's high sensitivity and second, it's lesser susceptibility to LER effects than LAL or rFC.
Test products with lowest CLCs thanks to our 0.004 EU/ml LoD
The CTL-MAT kit's high sensitivity gives you the flexibility to use higher (and higher) dilution factors, until you find one that best manages your product's low contaminant limit concentration (CLC) or interfering factors.
"Our CTL-MAT kit and services help you transfer your release testing method to the new gold standard with little hassle, lightning fast."
In 2020 we've onboarded some of the largest pharmaceuticals worldwide to using the CTL-MAT kit. From capital expenditure planning, lab set-up, storage, logistics, training, product specific validation to finally routine testing – we'll support you every step of the way.
"Since partnering with MAT BioTech, we've slashed the time, money and human resource allocated for validation and routine testing more than ever before"
100%
Customer Happiness score
Learn more about pyrogen testing
BACKGROUND
What the journey of keeping drugs safe from pyrogens has looked like: from Rabbit Pyrogen Tests, to Bacterial Endotoxin Tests and now the in-vitro MAT.
EDUCATION
What constitutes an exogenous versus an endogenous pyrogen and the difference between those that are endotoxin and non-endotoxin.
MARKET
What are the different types of MAT kit available?
What differentiates the commercialised MAT kits that are currently available on the market and how to pick the most suitable one.
You'll be in
good company.
Join some of the largest pharmaceutical and medical device companies in the world who partner with us for Monocyte Activation Testing.